CGC research shows how hyperthermia sensitises cancer cells to chemotherapy

Cancer Genomics Centre

Professor Ronald Kanaar from the Cancer Genomics Centre and his colleagues have now discovered that mild hyperthermia induces degradation of BRCA2, a protein that is necessary for DNA repair.

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Redefining plant systems biology: from cell to ecosystem

Centre for BioSystems Genomics

Researchers of the CBSG together with colleagues published an opinion article in the journal Trends in Plant Science. They argue that the coupling of aggregation levels in plant sciences, termed Integral Quantification of Biological Organisation (IQBiO), might enhance the abilities to generate new desired plant phenotypes.

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A metabolomic approach against chemoresistance

Netherlands Metabolomics Centre

Chemoresistance is one of the most prominent problems that cancer patients face, particularly when the cancer has disseminated, causing high morbidity and mortality. Dr Arjan Brenkman of NMC, together with several other researchers, characterised two specific lipids that prevent the action of a broad range of chemotherapy agents in cancer treatment.

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New shortcut through nuclear pore complex discovered

Netherlands Proteomics Centre

Netherlands Proteomics Centre (NPC) project leader Liesbeth Veenhoff and her colleagues have exposed a new shortcut by which membrane proteins are guided to the inner nuclear membrane. Unlike in the method known hitherto, the protein’s ‘address code’ is found to be attached to a long string that wriggles, as it were, through the membrane pore.

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Breakthrough towards more effective vaccines thanks to RNA

Netherlands Nutrigenomics Centre

Vaccination can be just as effective with dead bacteria as with live ones, as long as you inject them with the RNA of live bacteria. This finding was published in Nature by a team of American, French, Amsterdam and Wageningen researchers. Michael Müller, Scientific Director of the Netherlands Nutrigenomics Centre co-authored of the publication.

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